Error loading page.
Try refreshing the page. If that doesn't work, there may be a network issue, and you can use our self test page to see what's preventing the page from loading.
Learn more about possible network issues or contact support for more help.
Title details for Valley of Forgetting by Jennie Erin Smith - Available

Valley of Forgetting

Alzheimer's Families and the Search for a Cure

by Jennie Erin Smith
ebook
1 of 2 copies available
Borrow Read a sample Read a sample
1 of 2 copies available
"Valley of Forgetting reminds us that scientific progress is measured not only in breakthroughs but also through the sacrifices people make, the trust that is built. It is a tender story of the unshakable will to make meaning in the face of inexorable loss. . . . Smith elegantly captures what it means to love, to belong, to hold on to one another when so much is uncertain.” —Washington Post
The riveting account of a community from the remote mountains of Colombia whose rare and fatal genetic mutation is unlocking the secrets of Alzheimer’s disease

In the 1980s, a neurologist named Francisco Lopera traveled on horseback into the mountains seeking families with symptoms of dementia. For centuries, residents of certain villages near Medellín had suffered memory loss as they reached middle age, going on to die in their fifties. Lopera discovered that a unique genetic mutation was causing their rare hereditary form of early onset Alzheimer’s disease. Over the next forty years of working with the “paisa mutation” kindred, he went on to build a world-class research program in a region beset by violence and poverty.
In Valley of Forgetting, Jennie Erin Smith brings readers into the clinic, the laboratories, and the Medellín trial center where Lopera’s patients receive an experimental drug to see if Alzheimer’s can be averted. She chronicles the lives of people who care for sick parents, spouses, and siblings, all while struggling to keep their own dreams afloat. These Colombian families have donated hundreds of their loved ones’ brains to science and subjected themselves to invasive testing to help uncover how Alzheimer’s develops and whether it can be stopped. Findings from this unprecedented effort could hold the key to understanding and treating the disease, though it is unclear what, if anything, the families will receive in return.
Smith’s immersive storytelling brings this complex drama to life, inviting readers on a scientific journey that is as deeply moving as it is engrossing.

  • Creators

  • Publisher

  • Release date

    April 1, 2025

  • Formats

    • Kindle Book

    • OverDrive Read

      • ISBN: 9780525536093

    • EPUB ebook

      • ISBN: 9780525536093
      • File size: 1591 KB

  • Accessibility

    The publisher provides the following statement about the accessibility of the EPUB file supplied to OverDrive. Experiences may vary across reading systems. After borrowing the book, you may download the EPUB files to read in another reading system.

    Summary

    This ebook features mark-up that supports accessibility and enables compatibility with assistive technology. It has been designed to allow display properties to be modified by the reader. The file includes a table of contents, a defined reading order, and ARIA roles to identify key sections and improve the reading experience. A page list and page break locations help readers coordinate with the print edition. Headings allow readers to navigate the ebook quickly by level. Images are well described in conformance with WCAG 2.1 Level AA. There is a fully linked and navigable index. Colors meet WCAG 2.1 Level AA contrast standards. There are no hazards.

    Ways Of Reading

    • Appearance of the text and page layout can be modified according to the capabilities of the reading system (font family and font size, spaces between paragraphs, sentences, words, and letters, as well as color of background and text).

    • All content can be read as read aloud speech or dynamic braille.

    • Has alternative text descriptions for images.

    Conformance

    • The publication contains a conformance statement that it meets the EPUB Accessibility and WCAG 2 Level AA standard.

    • The publication was certified by Penguin Random House LLC.

    • This publication claims to meet EPUB Accessibility 1.1 WCAG 2.1 Level AA.

    Navigation

    • Table of contents to all chapters of the text via links.

    • Index with links to referenced entries.

    • Elements such as headings, tables, etc for structured navigation.

    Additional Information

    • Page breaks included

    • High contrast between text and background

    • Color is not the sole means of conveying information

  • Languages

    • English

  • Reviews

    Loading
    Loading

Formats

  • Kindle Book
  • OverDrive Read
  • EPUB ebook

subjects

Languages

  • English

Loading